Targeting Transcription Factors for Cancer Treatment
نویسندگان
چکیده
منابع مشابه
Targeting HOX transcription factors in prostate cancer
BACKGROUND The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been shown to promote cell proliferation and survival. The purpose of this study was to evaluate the expression of HOX genes in prostate cancer and to establish whether prostate canc...
متن کاملCREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.
Transcription factors are key regulators of the pattern of gene expression in a cell and directly control central processes such as proliferation, survival, self-renewal, and invasion. Given this critical role, the function of transcription factors is normally regulated closely, often through transient phosphorylation. Although transcription factors are not often directly modified by mutations ...
متن کاملA new fork for clinical application: targeting forkhead transcription factors in cancer.
Forkhead O transcription factors (FOXO) play a pivotal role in the regulation of a myriad of cellular functions including cell cycle arrest, cell death, and protection from stress stimuli. Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein kinase are known to phosphorylate FOXOs at different sites which cause FOXOs nuclear exclusion a...
متن کاملA Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors.
Mutations in transcription factor (TF) genes are frequently observed in tumors, often leading to aberrant transcriptional activity. Unfortunately, TFs are often considered undruggable due to the absence of targetable enzymatic activity. To address this problem, we developed CRAFTT, a computational drug-repositioning approach for targeting TF activity. CRAFTT combines ChIP-seq with drug-induced ...
متن کاملSpecific Transcription Factors Prognostic for Prostate Cancer
We have previously identified (M. Wang et aL, OncoL Res., in press, 1998) an enhancer element [human tissue inhibitor of metalloproteinase-1 enhancer-i (HTE)] for the human tissue inhibitor of metalloproteinase-1 promoter that binds a novel zinc finger, cysteine-rich transcription factor (CRTF). In this study, we have used electrophoretic mobifity shift assays to examine the relative level of e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23061479